Acute peripheral nerve recording characteristics of polymer-based longitudinal intrafascicular electrodes

Journal ArticleWe examined the recording characteristics of two different types of polymer-based longitudinal intrafascicular electrodes (LIFEs) in peripheral nerve: single-stranded (s-polyLIFEs) and multistranded (m-polyLIFEs). Recordings were also made from Pt-Ir wire-based electrodes (PtIrLIFEs) as a control. The electrodes were implanted in either tibial or medial gastrocnemius branches of the rabbit sciatic nerve, and in the sciatic nerve of rats. Recorded neural activity induced by manually elicited afferent neural activity showed that both polyLIFE versions performed comparably to PtIrLIFEs

Geometric Characterization of Local Changes in Tungsten Microneedle Tips after In-Vivo Insertion into Peripheral Nerves

Peripheral neural interfaces are used to connect the peripheral nervous system to high-tech robotic devices and computer interfaces. Soft materials are nowadays used to build the main structural part of these interfaces because they are able to mimic the mechanical properties of peripheral nerves. However, if on the one hand soft materials provide effective connections, reducing mechanical mismatch with nervous tissues and creating a close contact between active sites and neural fibers, on the other hand, most of them are not mechanically stable during implantation. As a consequence, tungsten (W) microneedles are used to insert soft neural interfaces, because they are able to pierce the peripheral nervous tissue because of their high stiffness. Nevertheless, this stiffness cannot prevent microneedles from local microscopic structural damage, even after successful insertions. In addition, the nature of this damage is not totally clear. Therefore, this work aimed at quantitatively investigating the phenomenological changes of the microneedles’ tip shape after insertion into the in vivo peripheral nerves. In particular, a quantification of the interactions between peripheral nerves and W microneedles was proposed through the Oliver-Pharr formula, and the interaction force was found to be directly proportional to the power < m > = 2.124 of the normalized indentation depth. Moreover, an experimental correlation between insertion force and the opening tip angle was described together with an assessment of the minimum diameter to effectively puncture the peripheral nervous tissue. Finally, a computational framework was presented to describe the local changes affecting the microneedles’ tip shape. This approach was able to detect a bulging phenomenon along with the microneedle tips with a characteristic amplitude of approximately 100 μm, and a folding phenomenon, with a characteristic mean amplitude of less than 20 μm, affecting the extreme ending sections of the microneedle tips. These geometrical changes were related to the synergistic action of interaction forces likely resulting in compression and elastic instability of the tip